Polymorphism and disease resistance of bovine major histocompatibility complex
نویسندگان
چکیده
منابع مشابه
Major Histocompatibility Complex: Polymorphism from Coevolution
There are many examples of pathogens adapting toward evasion of immune responses. Viruses, such as influenza, rapidly alter their genetic make-up, and each year there appear to be sufficient susceptible hosts that lack memory lymphocytes from previous influenza infections to give rise to a new epidemic (Both et al. 1983; Smith et al. 1999). During human immunodeficiency virus (HIV) infection, s...
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Human major histocompatibility complex (MHC) alleles can be used as markers for a wide variety of autoimmune and other disorders. The interpretation of and possible bases for these associations can be considered in relation to conserved extended MHC haplotypes (CEHs). The latter are fixed stretches of up to several million base pairs of genomic deoxyribonucleic acid (DNA). CEHs constitute at le...
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Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of balancing selection, we have examined a model equivalent to overdominance that confers heterozygote advantage. As discussed by A. Robertson, overdominance selection tends to maintain alleles that have more ...
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ژورنال
عنوان ژورنال: The journal of animal genetics
سال: 2007
ISSN: 1884-3883,1344-9265
DOI: 10.5924/abgri2000.35.51